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Research linking Ashkenazi Jews and cancer of the breast genes beset

Genetic research during the last decade has linked Ashkenazi Jewish ethnicity to an increased risk for hereditary breast cancer, So much so that certain gene mutations have become known as "Jewish ancestral versions, But a new study released in the November 2006 issue of the American Journal of Public Health challenges this population based approach, Warning that disparities in access to care and other unintended final outcomes for specific ethic groups can result, And may have previously occurred.

the analysis, Conducted by Columbia University College of Physicians Surgeons research, Notes that while three recognized cancers of the breast mutations are present in two three percent of the Ashkenazi Jewish population, Similar prevalence studies have not been carried out in other ethnic groups. in addition, The study finds that research linking the breast cancer mutations with Ashkenazi Jews has been beset by girls in spanish methodological issues that cast doubt on the use of ethnicity as the basis for genetic research on disease. "Focusing genetic studies on a specific ethnic group may confer disadvantage to that group and others. This finding in Ashkenazi Jews raises the risk of stigmatization and insurance or job elegance. For other social groups, It features a gap in access to testing and treatment,

The report cites a example of disparities that have occurred. as, Ashkenazi Jewish women provide access to an inexpensive test that detects the mutations at a cost of $415 compared with $2,975 for the test for non Ashkenazi Jewish women without known family variations. Other studies have found that Ashkenazi Jewish women with family histories of cancers of the breast are more than twice as likely as other women at similar risk to undergo testing for suspect genes.

dr. The interviews revealed how geneticists came to substitute ethnicity for genealogy and family tree as the most relevant indicator of risk.

Serendipity played a huge role. individuals had previously found a high prevalence of a mutation causing Tay Sachs disease in Ashkenazi Jews. inside of 20 years, One million Jews throughout the world had been tested for the Tay Sachs mutation, And scientific institutions had created large repositories of genetic samples that could then be screened for other mutations including those relevant to breast cancer but only in Ashkenazi Jews. Most scientists relied on study participants’ self id. Ashkenazi Jews are originated from Jews who lived in central and Eastern Europe, But a complex qualifications of migrations, And multiple cultural and orlando meanings of Ashkenazi, Makes self id problematic.

The study also illuminates how geneticists viewed Jewish history to support the theory of Ashkenazi genetic uniqueness. This decryption views the historic Ashkenazi Jewish population as isolated, And as having undergone extreme expansions and contractions. It attributes Ashkenazi Jewish genetic unique to "president effects, the idea that genetic mutations can take hold and spread within small, Geographically isolated communities, for example a group living alone on an island.

Although Ashkenazi Jews beautiful spanish women were never geographically cut off, Rothman declared that "Researchers made persecution the pogroms and massacres in Jewish history the same as geographic isolation,

The study noted that a great number of recent genetic surveys including among Spanish, chinese, dutch, Polish and Hispanic for women who live shown a high presence of the so called “Ancestral Jewish variations” In non Ashkenazi and non judaism groups. as an example, A large study of Spanish women with cancers of the breast reported that one of the three mutations accounted for 16.7 percent of all strains in the gene. Rothman mentioned.

Columbia University medical center provides international leadership in pre clinical and clinical research, In health and medical sciences education, And in unhurried care. The medical center trains future leaders and includes the dedicated work of many physicians, scientists, healthcare professionals, dental surgeons, And public scientific research at the College of Physicians Surgeons, the faculty of Dental Medicine, the teachers of Nursing, The postman School of Public Health, The biomedical sectors of the Graduate School of Arts and Sciences, And allied research centers and foundations.

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